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Mannose type O-glycan biosynthesis

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
UDP-D-xylose + Rib-ol-5-P-(->1)-Rib-ol-5-P-(->3)-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man6P-1-Ser/Thr <=> UDP + beta-D-Xyl-(1->4)-Rib-ol-5-P-(->1)-Rib-ol-5-P-(->3)-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man6P-1-Ser/Thr 2.4.2.61 alpha-dystroglycan beta1,4-xylosyltransferase

O-mannose_core_M3 + ATP <=> Phospho-core_M3 + ADP 2.7.1.183 glycoprotein-mannosyl O6-kinase

Phospho-core_M3 + CDP-ribitol <=> Rib-ol-5-P-(->3)-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man6P-1-Ser/Thr + CMP 2.7.8

UDP-N-acetyl-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-1-Ser/Thr <=> UDP + beta-D-GlcNAc-(1->6)-[beta-D-GlcNAc-(1->2)]-alpha-D-Man-1-Ser/Thr 2.4.1

beta-D-GlcNAc-(1->4)-alpha-D-Man-1-Ser/Thr + UDP-N-acetyl-D-galactosamine <=> O-mannose_core_M3 + UDP 2.4.1.313 protein O-mannose beta-1,3-N-acetylgalactosaminyltransferase

CTP + D-ribitol_5-phosphate + H+ <=> CDP-ribitol + diphosphate 2.7.7.40 D-ribitol-5-phosphate cytidylyltransferase

UDP-N-acetyl-D-glucosamine + alpha-D-Man-1-Ser/Thr <=> UDP + beta-D-GlcNAc-(1->2)-alpha-D-Man-1-Ser/Thr 2.4.1

dolichyl_phosphate_D-mannose + protein <=> dolichyl_phosphate + alpha-D-Man-1-Ser/Thr 2.4.1.109 dolichyl-phosphate-mannose---protein mannosyltransferase

alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->4)-beta-D-Xyl-(1->4)-Rib-ol-5-P-(->1)-Rib-ol-5-P-(->3)-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man6P-1-Ser/Thr + UDP-glucuronate <=> beta-D-GlcA-(1->3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->4)-beta-D-Xyl-(1->4)-Rib-ol-5-P-(->1)-Rib-ol-5-P-(->3)-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man6P-1-Ser/Thr + UDP 2.4.1

Rib-ol-5-P-(->3)-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man6P-1-Ser/Thr + CDP-ribitol <=> Rib-ol-5-P-(->1)-Rib-ol-5-P-(->3)-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man6P-1-Ser/Thr + CMP 2.7.8

beta-D-GlcA-(1->4)-beta-D-Xyl-(1->4)-Rib-ol-5-P-(->1)-Rib-ol-5-P-(->3)-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man6P-1-Ser/Thr + UDP-D-xylose <=> alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->4)-beta-D-Xyl-(1->4)-Rib-ol-5-P-(->1)-Rib-ol-5-P-(->3)-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man6P-1-Ser/Thr + UDP 2.4.2

UDP-N-acetyl-D-glucosamine + alpha-D-Man-1-Ser/Thr <=> UDP + beta-D-GlcNAc-(1->4)-alpha-D-Man-1-Ser/Thr 2.4.1.312 protein O-mannose beta-1,4-N-acetylglucosaminyltransferase

beta-D-Xyl-(1->4)-Rib-ol-5-P-(->1)-Rib-ol-5-P-(->3)-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man6P-1-Ser/Thr + UDP-glucuronate <=> beta-D-GlcA-(1->4)-beta-D-Xyl-(1->4)-Rib-ol-5-P-(->1)-Rib-ol-5-P-(->3)-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man6P-1-Ser/Thr + UDP 2.4.1

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